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Review
. 2010 Nov;8(11):1549-58.
doi: 10.1586/erc.10.137.

Pulmonary hypertension in women

Meredith E Pugh  1 , Anna R Hemnes
Affiliations
Review

Pulmonary hypertension in women

Meredith E Pugh et al. Expert Rev Cardiovasc Ther. 2010 Nov.

Abstract

Female predominance in pulmonary arterial hypertension (PAH) has been known for several decades and recent interest in the effects of sex hormones on the development of disease has substantially increased our understanding of this epidemiologic observation. Basic science data suggest a beneficial effect of estrogens in the pulmonary vasculature both acutely and chronically, which seems to contradict the known predilection in women. Recent human and rodent data have suggested that altered levels of estrogen, differential signaling and altered metabolism of estrogens in PAH may underlie the gender difference in this disease. Studies of the effects of sex hormones on the right ventricle in animal and human disease will further aid in understanding gender differences in PAH. This article focuses on the effects of sex hormones on the pulmonary vasculature and right ventricle on both a basic science and translational level.

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Figures

Figure 1
Figure 1. Sex hormone metabolism
2-MEOE2: 2-Methoxyestradiol; 2-OHE2: 2-Hydroxyestradiol; 4-MEOE2: 4-Methoxyestradiol; 4-OHE2: 4-Hydroxyestradiol; COMT: Catechol-O-methyltransferase; DHEA: Dehydroepiandrosterone.
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