HLA-DR6 association confers increased resistance to T. rubrum onychomycosis in Mexican Mestizos
- PMID: 21091674
- DOI: 10.1111/j.1365-4632.2010.04550.x
HLA-DR6 association confers increased resistance to T. rubrum onychomycosis in Mexican Mestizos
Abstract
Background: Onychomycosis is multifactorial in origin. Studies have suggested an autosomal dominant pattern of inheritance and human leukocyte antigen DR4 (HLA-DR4) has been shown to protect against onychomycosis in an Ashkenazi Jewish population.
Aim: This study investigates HLA class II association in a Mexican Mestizo population with Trichophyton rubrum onychomycosis.
Methods: This was a prospective case-control study. Mexican Mestizos with a clinical diagnosis of onychomycosis and culture positive for T. rubrum were recruited, together with age- and sex-matched controls. First-degree relatives were also investigated for onychomycosis. Case-control samples were HLA typed by polymerase chain reaction sequence-specific primer based analysis.
Results: Twenty-one cases and 42 controls were recruited with a mean age of 40 years (range: 18-58 years). HLA-DR6 was found in seven (33%) cases and 19 (45%) controls [P < 0.023, odds ratio (OR) = 0.088, 95% confidence interval (CI): 0.01-0.71]. Six (29%) cases and three (7%) controls had an affected child (P < 0.043, OR = 9.15, 95% CI: 1.07-78.31), and 13 (62%) cases and 12 (29%) controls had an affected first-degree relative (P < 0.02, OR = 4.0, 95% CI: 1.1-14.3).
Conclusions: These results suggest that HLA-DR6 confers protection against the development of onychomycosis in a Mexican Mestizo population. Having an affected first-degree relative significantly increases the risk of onychomycosis, suggesting genetic susceptibility.
© 2010 The International Society of Dermatology.
Similar articles
-
Analysis of genetic polymorphism of the HLA-B and HLA-DR loci in patients with dermatophytic onychomycosis and in their first-degree relatives.Actas Dermosifiliogr. 2012 Jan;103(1):59-62. doi: 10.1016/j.adengl.2011.03.017. Epub 2012 Mar 26. Actas Dermosifiliogr. 2012. PMID: 22456594
-
Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes.Tissue Antigens. 2007 Feb;69(2):161-9. doi: 10.1111/j.1399-0039.2006.00738.x. Tissue Antigens. 2007. PMID: 17257319
-
Increased frequency of HLA-DR3 and complotype SCO1 in Mexican mestizo children with amoebic abscess of the liver.Parasite Immunol. 1996 Oct;18(10):491-8. doi: 10.1046/j.1365-3024.1996.d01-16.x. Parasite Immunol. 1996. PMID: 9226686
-
A Systematic Review and Meta-Analysis of Human Leukocyte Antigen-DR (HLA-DR) in Onychomycosis: HLA-DR8 Confers Susceptibility.Cureus. 2024 Sep 11;16(9):e69162. doi: 10.7759/cureus.69162. eCollection 2024 Sep. Cureus. 2024. PMID: 39398739 Free PMC article. Review.
-
Genetic predisposition--understanding underlying mechanisms of onychomycosis.J Eur Acad Dermatol Venereol. 2005 Sep;19 Suppl 1:17-9. doi: 10.1111/j.1468-3083.2005.01283.x. J Eur Acad Dermatol Venereol. 2005. PMID: 16120201
Cited by
-
Identifying genetically driven clinical phenotypes using linear mixed models.Nat Commun. 2016 Apr 25;7:11433. doi: 10.1038/ncomms11433. Nat Commun. 2016. PMID: 27109359 Free PMC article.
-
Low DEFB4 copy number and high systemic hBD-2 and IL-22 levels are associated with dermatophytosis.J Invest Dermatol. 2015 Mar;135(3):750-758. doi: 10.1038/jid.2014.369. Epub 2014 Sep 1. J Invest Dermatol. 2015. PMID: 25178103
-
Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi.Front Cell Infect Microbiol. 2020 Feb 28;10:69. doi: 10.3389/fcimb.2020.00069. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32185141 Free PMC article. Review.
-
Genetic Predisposition and its Heredity in the Context of Increased Prevalence of Dermatophytoses.Mycopathologia. 2021 May;186(2):163-176. doi: 10.1007/s11046-021-00529-1. Epub 2021 Feb 1. Mycopathologia. 2021. PMID: 33523393 Free PMC article. Review.
-
Two Novel Human Leukocyte Antigen Alleles Are Associated with Decreased Risk of Onychomycosis in a Large Cohort of Danish Blood Donors.Skin Appendage Disord. 2023 Jun;9(3):195-202. doi: 10.1159/000529092. Epub 2023 Feb 15. Skin Appendage Disord. 2023. PMID: 37325286 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials