Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 May;10(5):1931-9.
doi: 10.1128/mcb.10.5.1931-1939.1990.

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals

X M Cao  1 , R A Koski, A Gashler, M McKiernan, C F Morris, R Gaffney, R V Hay, V P Sukhatme
Affiliations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals

X M Cao et al. Mol Cell Biol. 1990 May.

Abstract

Egr-1 is an immediate-early response gene induced by diverse signals that initiate growth and differentiation. Its cDNA sequence predicts a protein with zinc fingers. We have generated an antiserum to the Egr-1 gene product and identified it as an 80-kilodalton short-lived protein in serum-stimulated mouse fibroblasts. The rat Egr-1 product has also been identified in nerve growth factor-induced PC12 cells. In addition, we show by cell fractionation and immunocytochemistry that the Egr-1 protein is located in the nucleus. We also demonstrate that it is phosphorylated. In vitro-generated Egr-1 protein binds with high affinity to the sequence CGCCCCCGC in a zinc-dependent manner.

PubMed Disclaimer

References

    1. Nature. 1984 Oct 4-10;311(5985):433-8 - PubMed
    1. Neuron. 1988 May;1(3):183-8 - PubMed
    1. FEBS Lett. 1985 Jul 8;186(2):271-4 - PubMed
    1. Cell. 1987 Jan 16;48(1):79-89 - PubMed
    1. Mol Cell Biol. 1986 Dec;6(12):4450-7 - PubMed

Publication types

MeSH terms