Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010;12(6):147.
doi: 10.1186/ar3175. Epub 2010 Nov 9.

The autoimmune tautology

Juan-Manuel Anaya
Review

The autoimmune tautology

Juan-Manuel Anaya. Arthritis Res Ther. 2010.

Abstract

Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune diseases within an individual (that is, polyautoimmunity) and within members of a nuclear family (that is, familial autoimmunity). Second, physiopathologic evidence indicates that the pathologic mechanisms may be similar among autoimmune diseases. Lastly, genetic evidence shows that autoimmune phenotypes might represent pleiotropic outcomes of the interaction of non-specific disease genes.

PubMed Disclaimer

Comment on

References

    1. Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P. Yorkshire Early Arthritis (YEAR) Consortium, Biologics in RA Control (BIRAC) Consortium. Thomson W, Worthington J, Barton A. Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther. 2010;12:R175. doi: 10.1186/ar3139. - DOI - PMC - PubMed
    1. Wandstrat A, Wakeland E. The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nat Immunol. 2001;2:802–809. doi: 10.1038/ni0901-802. - DOI - PubMed
    1. Anaya JM, Corena R, Castiblanco J, Rojas-Villarraga A, Shoenfeld Y. The kaleidoscope of autoimmunity. Multiple autoimmune syndromes and familial autoimmunity. Expert Rev Clin Immunol. 2007;3:623–635. doi: 10.1586/1744666X.3.4.623. - DOI - PubMed
    1. Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, Trent JM. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci USA. 1998;95:9979–9984. doi: 10.1073/pnas.95.17.9979. - DOI - PMC - PubMed
    1. Anaya JM, Gomez LM, Castiblanco J. Is there a common genetic basis for autoimmune diseases? Clin Dev Immunol. 2006;13:185–195. doi: 10.1080/17402520600876762. - DOI - PMC - PubMed

MeSH terms