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. 2010 Nov 22:5:22.
doi: 10.1186/1750-9378-5-22.

Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?

Riccardo Dolcetti  1 , Antonino Carbone
Affiliations

Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?

Riccardo Dolcetti et al. Infect Agent Cancer. .

Abstract

Epstein-Barr virus is pathogenically associated with a well defined group of lymphoid and epithelial tumors in which the virus directly drives transformation of infected cells. Recent evidence however indicates that this virus may infect a subpopulation of tumor cells in patients with chronic lymphocytic leukemia (CLL) and EBV infection has been also associated with Richter transformation in a fraction of cases. We herein review available data suggesting a possible role of EBV as a direct or micro-environmental progression factor in a subset of CLL.

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Figures

Figure 1
Figure 1
Richter's transformation of a CLL case. In situ EBER hybridization shows nuclear staining in giant Hodgkin/Reed-Sternberg-like cells (660×).
See this image and copyright information in PMC

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