Heterogeneity of tumor cells from a single mouse mammary tumor
- PMID: 210930
Heterogeneity of tumor cells from a single mouse mammary tumor
Abstract
By the use of a variety of cell culture and separation methods, four cell lines were isolated from a single autochthonous BALB/cfC3H mammary tumor. These lines differ markedly from each other in culture morphology, various in vitro growth properties, expression of murine mammary tumor virus antigen, and karyotype, yet all four lines are tumorigenic in normal, syngeneic hosts, yielding tumors of generally similar histology, although distinct from the original neoplasm. Three of the four lines have been cloned from soft agar. The clones exhibit the same growth properties as the lines from which they were derived. Karyotypic analysis of the parent tumor revealed the presence of cells with heterogeneous numbers of chromosomes similar to those seen in the isolated lines, suggesting both the presence of these distinct cell types in the original neoplasm and a genetic origin of the diversity.
Similar articles
-
Heterogeneity of expression and induction of mouse mammary tumor virus antigens in mouse mammary tumors.Cancer Res. 1982 Nov;42(11):4325-9. Cancer Res. 1982. PMID: 6290031
-
Characteristics of mammary tumor cultures from four mouse strains infected with mammary tumor virus.Cancer Res. 1975 Feb;35(2):370-3. Cancer Res. 1975. PMID: 162873
-
Kinetics of responses to tumor antigens and mouse mammary tumor virus in BALB/cCrgl and BALB/cfC3H mice.J Natl Cancer Inst. 1981 Jan;66(1):191-6. J Natl Cancer Inst. 1981. PMID: 6256573
-
Mouse mammary tumor virus associated antigens and superantigens--immuno-molecular correlates of neoplastic progression.Semin Cancer Biol. 1993 Jun;4(3):205-13. Semin Cancer Biol. 1993. PMID: 8391342 Review.
-
Mammary tumor heterogeneity.Symp Fundam Cancer Res. 1983;36:209-21. Symp Fundam Cancer Res. 1983. PMID: 6382505 Review. No abstract available.
Cited by
-
The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain.Pain. 2016 Nov;157(11):2605-2616. doi: 10.1097/j.pain.0000000000000681. Pain. 2016. PMID: 27482630 Free PMC article.
-
RMZ: a new cell line from a human alveolar rhabdomyosarcoma. In vitro expression of embryonic myosin.Br J Cancer. 1986 Dec;54(6):1009-14. doi: 10.1038/bjc.1986.273. Br J Cancer. 1986. PMID: 3801282 Free PMC article.
-
Extensive intra-tumor heterogeneity in primary human glial tumors as a result of locus non-specific genomic alterations.J Neurooncol. 2000 May;48(1):1-12. doi: 10.1023/a:1006435201961. J Neurooncol. 2000. PMID: 11026691
-
N-linked oligosaccharides and metastatic propensity in in vivo selected mouse mammary adenocarcinoma cells.Clin Exp Metastasis. 1999 Jul;17(5):437-44. doi: 10.1023/a:1006629119030. Clin Exp Metastasis. 1999. PMID: 10651311
-
A murine model of bone marrow micrometastasis in breast cancer.Clin Exp Metastasis. 2002;19(7):561-9. doi: 10.1023/a:1020958915361. Clin Exp Metastasis. 2002. PMID: 12498385
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Molecular Biology Databases
Research Materials