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. 2011 May 30;187(3):454-6.
doi: 10.1016/j.psychres.2010.10.008. Epub 2010 Nov 18.

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Paolo Gravina  1 , Ilaria Spoletini, Silvia Masini, Alessandra Valentini, Diego Vanni, Eleonora Paladini, Paola Bossù, Carlo Caltagirone, Giorgio Federici, Gianfranco Spalletta, Sergio Bernardini
Affiliations

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Paolo Gravina et al. Psychiatry Res. .

Abstract

Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.

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