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. 1978 Oct;38(10):3310-4.

Spontaneous esophageal carcinoma and epithelial cell line of an adult rhesus monkey

H Rabin, R H Neubauer, M A Gonda, W A Nelson-Rees, H P Charman, M G Valerio
  • PMID: 210934

Spontaneous esophageal carcinoma and epithelial cell line of an adult rhesus monkey

H Rabin et al. Cancer Res. 1978 Oct.

Abstract

A continuous epithelial cell line, 816A, was established from a lymph node of an adult rhesus monkey with metastatic esophageal carcinoma. These cells are characterized by the presence of desmosomes and a markedly heteroploid karyotype. At a relatively early culture age, electron microscopy showed both budding and extracellular type C virus. Antigen reactive with antisera to Mason-Pfizer monkey virus was observed by complement-fixation. The level of this antigen decreased with increased culture age. To our knowledge, the 816A cells represent the only established simian or human cell line of esophageal carcinoma origin.

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