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Review
. 2011 Jan;16(1-2):58-64.
doi: 10.1016/j.drudis.2010.11.003. Epub 2010 Nov 18.

Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

Guodong Chen  1 , Bethanne M Warrack, Angela K Goodenough, Hui Wei, David B Wang-Iverson, Adrienne A Tymiak
Affiliations
Review

Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

Guodong Chen et al. Drug Discov Today. 2011 Jan.

Abstract

Mass spectrometry (MS) has become a powerful technology in the discovery and development of protein therapeutics in the biopharmaceutical industry. This review article describes recent developments and future trends in the characterization of protein therapeutics using MS. We discuss top-down MS for the characterization of protein modifications, hydrogen/deuterium exchange MS and ion mobility MS methods for higher order protein structure studies. Quantitative analysis of protein therapeutics (in vivo) by MS as an orthogonal approach to immunoassay for pharmacokinetics studies will also be illustrated.

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