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Review
. 2011 Feb;31(1):133-40.
doi: 10.1016/j.iac.2010.09.013.

The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases

Gailen D Marshall Jr  1
Affiliations
Review

The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases

Gailen D Marshall Jr. Immunol Allergy Clin North Am. 2011 Feb.

Abstract

Psychological stress has known effects on the immune system, including impacting effector and regulatory components. This can result in increased susceptibility to various infections, latent virus reactivation, and impact on immunoregulatory circuits. One of the great challenges in translational research is defining the risks associated with stress in specific patient populations and individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.

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References

    1. Ader R. Psychoneuroimmunology. ILAR J. 1998;39(1):27–29. - PubMed
    1. Cohen S. Keynote Presentation at the Eight International Congress of Behavioral Medicine: the Pittsburgh common cold studies: psychosocial predictors of susceptibility to respiratory infectious illness. Int J Behav Med. 2005;12(3):123–131. - PMC - PubMed
    1. Agarwal SK, Marshall GD., Jr Stress effects on immunity and its application to clinical immunology. Clin Exp Allergy. 2001;31:25–31. - PubMed
    1. Rabin B. Stress: A system of thee whole. In: Ader R, editor. Pyschoneuroimmunology. 4th ed. Newy York: Elsevier; 2007. pp. 709–722.
    1. Webster JI, Tonelli L, Sternberg EM. Neuroendocrine regulation of immunity. Annu Rev Immunol. 2002;20:125–163. - PubMed

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