Comment
doi: 10.1016/j.molcel.2010.11.013.
ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation
Affiliations
- PMID: 21095578
- DOI: 10.1016/j.molcel.2010.11.013
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Comment
ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation
Mol Cell.
.
Free article
Abstract
Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1.
Copyright © 2010 Elsevier Inc. All rights reserved.
Comment on
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mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.Mol Cell. 2010 Nov 24;40(4):509-20. doi: 10.1016/j.molcel.2010.10.030. Mol Cell. 2010. PMID: 21095582 Free PMC article.
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