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Comment
. 2010 Nov 24;40(4):501-2.
doi: 10.1016/j.molcel.2010.11.013.

ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation

Sang Gyun Kim  1 , Andrew Y Choo, John Blenis
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Comment

ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation

Sang Gyun Kim et al. Mol Cell. .
Free article

Abstract

Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1.

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