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Case Reports
. 1990;38(1):93-5.
doi: 10.1007/BF00314813.

Possible protein binding displacement interaction between glibenclamide and metolazone

S George  1 , A McBurney, A Cole
Affiliations
Case Reports

Possible protein binding displacement interaction between glibenclamide and metolazone

S George et al. Eur J Clin Pharmacol. 1990.

Abstract

The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.

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