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. 1990 Mar;44(3):186-9.
doi: 10.1111/j.1600-0609.1990.tb00374.x.

Correlation between neopterin, interferon-gamma and haemoglobin in patients with haematological disorders

H Denz  1 , D Fuchs, H Huber, D Nachbaur, G Reibnegger, J Thaler, E R Werner, H Wachter
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Correlation between neopterin, interferon-gamma and haemoglobin in patients with haematological disorders

H Denz et al. Eur J Haematol. 1990 Mar.

Abstract

In this study, we further investigated a possible link between activation of cell-mediated immunity and anaemia in patients with haematological neoplasias. We compared serum concentrations of interferon-gamma and neopterin with haemoglobin levels. Significantly increased interferon-gamma and neopterin concentrations indicated persistent activation of cell-mediated immunity. Neopterin levels correlated significantly to interferon-gamma concentrations and inversely to haemoglobin levels. The data indicate an association between activated macrophages and the development of anaemia in patients with haematological neoplasias.

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