Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan;39(Database issue):D11-4.
doi: 10.1093/nar/gkq1168. Epub 2010 Nov 21.

COMBREX: a project to accelerate the functional annotation of prokaryotic genomes

Affiliations

COMBREX: a project to accelerate the functional annotation of prokaryotic genomes

Richard J Roberts et al. Nucleic Acids Res. 2011 Jan.

Abstract

COMBREX (http://combrex.bu.edu) is a project to increase the speed of the functional annotation of new bacterial and archaeal genomes. It consists of a database of functional predictions produced by computational biologists and a mechanism for experimental biochemists to bid for the validation of those predictions. Small grants are available to support successful bids.

PubMed Disclaimer

References

    1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995;269:496–512. - PubMed
    1. Galperin MY, Koonin EV. From complete genome sequence to ‘complete’ understanding? Trends Biotechnol. 2010;28:398–406. - PMC - PubMed
    1. Brenner SE. Errors in genome annotation. Trends Genet. 1999;15:132–133. - PubMed
    1. Schnoes AM, Brown SD, Dodevski I, Babbitt PC. Annotation error in public databases: misannotation of molecular function in enzyme superfamilies. PLoS Comp. Biol. 2009;5:e1000605. - PMC - PubMed
    1. Green ML, Karp PA. Genome annotation errors in pathway databases due to semantic ambiguity in partial EC numbers. Nucleic Acids Res. 2005;33:4035–4039. - PMC - PubMed

Publication types