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Review
. 2011 Jan-Feb;3(1):3-16.
doi: 10.4161/mabs.3.1.14110. Epub 2011 Jan 1.

Targeting antibodies to the cytoplasm

Andrea L J Marschall  1 , André Frenzel, Thomas Schirrmann, Manuela Schüngel, Stefan Dübel
Affiliations
Review

Targeting antibodies to the cytoplasm

Andrea L J Marschall et al. MAbs. 2011 Jan-Feb.

Abstract

A growing number of research consortia are now focused on generating antibodies and recombinant antibody fragments that target the human proteome. A particularly valuable application for these binding molecules would be their use inside a living cell, e.g., for imaging or functional intervention. Animal-derived antibodies must be brought into the cell through the membrane, whereas the availability of the antibody genes from phage display systems allows intracellular expression. Here, the various technologies to target intracellular proteins with antibodies are reviewed.

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Figures

Figure 1
Figure 1
The four major approaches to deliver antibodies into a cell.
See this image and copyright information in PMC

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