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. 2011 Jan 28;25(3):385-7.
doi: 10.1097/QAD.0b013e328341b86a.

Protective interleukin-28B genotype affects hepatitis C virus clearance, but does not contribute to HIV-1 control in a cohort of African-American elite controllers/suppressors

Maria Salgado  1 , Gregory D Kirk, Andrea Cox, Alleluiah Rutebemberwa, Yvonne Higgins, Jacquie Astemborski, David L Thomas, Chloe L Thio, Mark S Sulkowski, Joel N Blankson
Affiliations

Protective interleukin-28B genotype affects hepatitis C virus clearance, but does not contribute to HIV-1 control in a cohort of African-American elite controllers/suppressors

Maria Salgado et al. AIDS. .

Abstract

We tested the hypothesis that a single nucleotide polymorphism (SNP) located near the interleukin-28B gene is associated with the control of hepatitis C virus and HIV-1 replication in elite controllers/suppressors. We show here that the protective genotype is not overrepresented in elite controllers/suppressors compared with HIV-1-seronegative patients and HIV-1-infected patients with viral loads more than 10 000 copies/ml. Thus, it appears that this SNP is not associated with the elite control of HIV-1 infection.

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References

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