Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan 14;25(2):269-71.
doi: 10.1097/QAD.0b013e328341b84e.

Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline

Norma I Rallon  1 , Clara Restrepo, Susanna Naggie, Mariola Lopez, Jorge Del Romero, David Goldstein, John McHutchison, Vincent Soriano, Jose M Benito
Affiliations

Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline

Norma I Rallon et al. AIDS. .

Abstract

The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon-ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.

PubMed Disclaimer

Publication types

LinkOut - more resources