Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Feb;81(2):115-21.
doi: 10.1111/j.1349-7006.1990.tb02536.x.

A case-control study of male colorectal cancer in Aichi Prefecture, Japan: with special reference to occupational activity level, drinking habits and family history

I Kato  1 , S Tominaga, A Ikari
Affiliations

A case-control study of male colorectal cancer in Aichi Prefecture, Japan: with special reference to occupational activity level, drinking habits and family history

I Kato et al. Jpn J Cancer Res. 1990 Feb.

Abstract

The relationships of occupational activity level, drinking habits and family history of cancer to the risk of male colorectal cancer by subsites were investigated in a case-control study involving 1,716 cases with colon cancer, 1,611 cases with rectal cancer and 16,600 controls with other sites of cancer identified from the Aichi Cancer Registry, Japan 1979-1987. An occupation with a low activity level was associated with an increased risk of colorectal cancer; the age-adjusted relative risk (RR) compared to the high activity level group was 1.92 (95% confidence interval (CI): 1.38-2.67) for proximal colon cancer, 1.52 (95% CI: 1.19-1.94) for distal colon cancer and 1.38 (95% CI: 1.17-1.62) for rectal cancer. Beer drinkers showed an increased risk of colorectal cancer; the age-adjusted RR was 1.49 (95% CI: 1.13-1.95) for proximal colon cancer, 1.65 (95% CI: 1.34-2.04) for distal colon cancer and 1.88 (95% CI: 1.62-2.18) for rectal cancer. The RR for family history of colorectal cancer was 3.40 (95% CI: 2.19-5.29) for proximal colon cancer, 2.54 (95% CI: 1.73-3.75) for distal colon cancer and 1.78 (95% CI: 1.28-2.49) for rectal cancer. Multivariate analysis controlled for age, residence, marital status and smoking in addition to occupational activity level, beer drinking and family history of colorectal cancer did not materially change the RRs. When these three variables were combined, the RR was 15.72 (95% CI: 5.40-45.78) for proximal colon cancer, 10.55 (95% CI: 4.24-26.27) for distal colon cancer and 6.69 (95% CI: 3.12-14.36) for rectal cancer.

PubMed Disclaimer

References

    1. ) Muir , C. , Waterhouse , J. , Mack , T. , Powell , J. and Whelan , S. “ Cancer Incidence in Five Continents. V ,” IARC Sci. Publ. No. 88 ( 1987. ). IARC; , Lyon .
    1. ) Kurihara , M. , Aoki , K. and Tominaga , S. “ Cancer Mortality Statistics in the World ” ( 1984. ). The University Nagoya Press; , Nagoya .
    1. ) Kato , I. , Tominaga , S. and Kuroishi , T.Per capita foods/nutrients intake and mortality from gastrointestinal cancers in Japan . Jpn. J. Cancer Res. , 78 , 453 – 459 ( 1987. ). - PubMed
    1. ) Drasar , B. S. and Irving , D.Environmental factors and cancer of the colon and breast . Br. J. Cancer , 27 , 167 – 172 ( 1973. ). - PMC - PubMed
    1. ) Armstrong , B. and Doll , R.Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices . Int. J. Cancer , 15 , 617 – 631 ( 1975. ). - PubMed

LinkOut - more resources