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Comment
. 2010 Dec;12(12):1126-8.
doi: 10.1038/ncb1210-1126. Epub 2010 Nov 21.

Dynein at odd angles?

Adam G Hendricks, Jacob E Lazarus, Erika L F Holzbaur
Comment

Dynein at odd angles?

Adam G Hendricks et al. Nat Cell Biol. 2010 Dec.

Abstract

Cytoplasmic dynein drives vesicular transport from the periphery to the cell body of neurons. Missense mutations in the dynein tail domain cause neurodegenerative disease in mouse models. new data on the effect of one such dynein mutation provide insight into the intramolecular communication and flexible stepping of this essential cellular motor.

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