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. 2011 Jan;7(1):19-21.
doi: 10.1038/nchembio.485. Epub 2010 Nov 21.

Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate

Hiroshi Maeda  1 , Heejin Yoo, Natalia Dudareva
Affiliations

Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate

Hiroshi Maeda et al. Nat Chem Biol. 2011 Jan.

Abstract

The aromatic amino acids L-phenylalanine and L-tyrosine and their plant-derived natural products are essential in human and plant metabolism and physiology. Here we identified Petunia hybrida and Arabidopsis thaliana genes encoding prephenate aminotransferases (PPA-ATs), thus completing the identification of the genes involved in phenylalanine and tyrosine biosyntheses. Biochemical and genetic characterization of enzymes showed that PPA-AT directs carbon flux from prephenate toward arogenate, making the arogenate pathway predominant in plant phenylalanine biosynthesis.

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