Cell cycle: Disposing of SETD8

Comment

Rachel David. Nat Rev Mol Cell Biol. 2010 Dec.

. 2010 Dec;11(12):819.

doi: 10.1038/nrm3020.

No abstract available

Comment on

CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.
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CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.
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Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D. Oda H, et al. Mol Cell. 2010 Nov 12;40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28. Mol Cell. 2010. PMID: 21035370 Free PMC article.