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Review
. 2010 Dec;10(12):819-23.
doi: 10.1038/nrc2962. Epub 2010 Nov 24.

SIRT1: recent lessons from mouse models

Daniel Herranz  1 , Manuel Serrano
Affiliations
Review

SIRT1: recent lessons from mouse models

Daniel Herranz et al. Nat Rev Cancer. 2010 Dec.

Abstract

The family of protein deacetylases represented by yeast Sir2 has been the focus of intense investigation because of the longevity activity of Sir2 in yeast, worms and flies. Research in mammals has mainly focused on SIRT1, the closest homologue of Sir2. Emerging evidence from mouse models is yielding a sharper picture, in which SIRT1 is a potent protector from ageing-associated pathologies, such as diabetes, liver steatosis, cardiovascular disease, neurodegeneration and, importantly, various types of cancer.

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Figures

Figure 1
Figure 1. Summary of the main mechanisms through which Sirt1 protects from metabolic damage and cancer
The left panel shows the main mechanisms by which Sirt1, through direct deacetylation, protects from metabolic damage. Other mechanisms are mentioned in the text. The right panel shows the three mechanisms reported so far supporting cancer protection by Sirt1 in mice.
See this image and copyright information in PMC

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