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Review
. 2011 Feb;68(3):397-404.
doi: 10.1007/s00018-010-0581-6. Epub 2010 Nov 20.

HLA-G in organ transplantation: towards clinical applications

Frederic Deschaseaux  1 , Diego Delgado, Vito Pistoia, Massimo Giuliani, Fabio Morandi, Antoine Durrbach
Affiliations
Review

HLA-G in organ transplantation: towards clinical applications

Frederic Deschaseaux et al. Cell Mol Life Sci. 2011 Feb.

Erratum in

  • Cell Mol Life Sci. 2011 Feb;68(3):405

Abstract

HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.

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