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Review
. 2011 Feb;68(3):397-404.
doi: 10.1007/s00018-010-0581-6. Epub 2010 Nov 20.

HLA-G in organ transplantation: towards clinical applications

Frederic Deschaseaux  1 , Diego Delgado, Vito Pistoia, Massimo Giuliani, Fabio Morandi, Antoine Durrbach
Affiliations
Review

HLA-G in organ transplantation: towards clinical applications

Frederic Deschaseaux et al. Cell Mol Life Sci. 2011 Feb.

Erratum in

  • Cell Mol Life Sci. 2011 Feb;68(3):405

Abstract

HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.

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References

    1. Fuzzi B, et al. HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy. Eur J Immunol. 2002;32:311–315. doi: 10.1002/1521-4141(200202)32:2<311::AID-IMMU311>3.0.CO;2-8. - DOI - PubMed
    1. Jurisicova A, Casper RF, MacLusky NJ, Mills GB, Librach CL. HLA-G expression during preimplantation human embryo development. Proc Natl Acad Sci USA. 1996;93:161–165. doi: 10.1073/pnas.93.1.161. - DOI - PMC - PubMed
    1. Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ, DeMars R. A class I antigen, HLA-G, expressed in human trophoblasts. Science. 1990;248:220–223. doi: 10.1126/science.2326636. - DOI - PubMed
    1. Yie SM, Xiao R, Librach CL. Progesterone regulates HLA-G gene expression through a novel progesterone response element. Hum Reprod. 2006;21:2538–2544. doi: 10.1093/humrep/del126. - DOI - PubMed
    1. Houlihan JM, Biro PA, Harper HM, Jenkinson HJ, Holmes CH. The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G. J Immunol. 1995;154:5665–5674. - PubMed

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