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Comparative Study
. 2011 Mar;42(1):40-5.
doi: 10.1007/s12029-010-9228-y.

Comparison of two diverse populations, British Columbia, Canada, and Ardabil, Iran, indicates several variables associated with gastric and esophageal cancer survival

Morteza Bashash  1 , Parvin Yavari, T Greg Hislop, Amil Shah, Alireza Sadjadi, Masoud Babaei, Nhu Le, Angela Brooks-Wilson, Reza Malekzadeh, Chris Bajdik
Affiliations
Comparative Study

Comparison of two diverse populations, British Columbia, Canada, and Ardabil, Iran, indicates several variables associated with gastric and esophageal cancer survival

Morteza Bashash et al. J Gastrointest Cancer. 2011 Mar.

Abstract

Background: Geographic variation and temporal trends in the epidemiology of esophageal and gastric cancers vary according to both tumor morphology and organ subsite. This study compares 1-year survival of gastric and esophageal cancers between two distinct populations: British Columbia (BC), Canada, and Ardabil, Iran.

Methods: Data for invasive primary esophageal and gastric cancer patients were obtained from the population-based cancer registries for BC and Ardabil. The relative survival rate was calculated using WHO Statistical Information System (WHOSIS) life-tables for each country. Chi-square and Fisher's exact tests were used to compare survival differences between BC and Ardabil. T-tests, chi-square tests, and Fisher's exact test were used to compare patient characteristics and tumor factors between the populations.

Results: The overall 1-year age-standardized relative survivals for gastric cancer were 48% and 21% in BC and Ardabil, respectively (p < 0.01). The overall 1-year age-standardized relative survival for esophageal cancer was 33% and 17% in BC and Ardabil, respectively (p < 0.05). Overall and separately for each gender, age group, tumor location, and histology, there was greater 1-year survival of the gastric cancer patients in BC compared to Ardabil. For esophageal cancer; patients under age 65, patients with tumors in the middle or upper third of esophagus, and patients with squamous cell carcinoma had significantly better survival in BC than in Ardabil.

Conclusion: Findings of this study point to differences in disease characteristics and patient factors, not solely differences in healthcare systems, as being responsible for the survival difference in these populations.

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Figures

Fig. 1
Fig. 1
Overall 1-year age-standardized survival rates for gastric cancer cases in Ardabil (Iran) and British Columbia (Canada). Bars are ± standard error
Fig. 2
Fig. 2
Overall 1-year age-standardized survival rates for esophageal cancer cases in Ardabil (Iran) and British Columbia (Canada). Bars are ± standard error
See this image and copyright information in PMC

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