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. 2010 Nov 28;16(44):5629-34.
doi: 10.3748/wjg.v16.i44.5629.

Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines

Feng Ma  1 , Ye Chen, Jing Li, He-Ping Qing, Ji-De Wang, Ya-Li Zhang, Bei-Guo Long, Yang Bai
Affiliations

Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines

Feng Ma et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the anti-Helicobacter pylori (H. pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.

Methods: A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H. pylori Sydney strain 1 was performed with broth dilution method. Anti-H. pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).

Results: The water extract from Rhizoma Coptidis, Radix Scutellariae and Radix isatidis could significantly inhibit the H. pylori activity with their MIC less than 7.8 mg/mL, suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H. pylori infection.

Conclusion: Rhizoma Coptidis, Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H. pylori.

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References

    1. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311–1315. - PubMed
    1. Goodwin CS, Mendall MM, Northfield TC. Helicobacter pylori infection. Lancet. 1997;349:265–269. - PubMed
    1. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA. 1994;272:65–69. - PubMed
    1. Schistosomes , liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum. 1994;61:1–241. - PubMed
    1. Sepulveda AR, Coelho LG. Helicobacter pylori and gastric malignancies. Helicobacter. 2002;7 Suppl 1:37–42. - PubMed

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