doi: 10.1016/0304-3940(90)90341-6.
MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain
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- PMID: 2110635
- DOI: 10.1016/0304-3940(90)90341-6
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MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain
Neurosci Lett.
.
Abstract
MK-801, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK-801 is dose-and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0 mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK-801 is unclear; however, the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site.
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