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. 1990 Mar 26;111(1-2):39-45.
doi: 10.1016/0304-3940(90)90341-6.

MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain

M Dragunow  1 , R L Faull
Affiliations

MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain

M Dragunow et al. Neurosci Lett. .

Abstract

MK-801, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK-801 is dose-and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0 mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK-801 is unclear; however, the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site.

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