doi: 10.1016/j.bmcl.2010.10.026.
Epub 2010 Oct 13.
Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3
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- PMID: 21106455
- DOI: 10.1016/j.bmcl.2010.10.026
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Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3
Bioorg Med Chem Lett.
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Abstract
Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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