Molecular and cellular radiobiological effects of Auger emitting radionuclides
- PMID: 21106639
- PMCID: PMC3108272
- DOI: 10.1093/rpd/ncq385
Molecular and cellular radiobiological effects of Auger emitting radionuclides
Abstract
Although the general radiobiologic principles underlying external beam therapy and radionuclide therapy are similar, significant differences in the biophysical and radiobiologic effects from the two types of radiation continue to accumulate. Here, I will address the unique features that distinguish the molecular and cellular radiobiological effects of Auger electron-emitting radionuclides consequent to (1) the physical characteristics of the decaying atom and its subcellular localisation, (2) DNA topology and (3) the bystander effect. Based on these experimental findings, I postulate that the ability of track structural simulations as primary tools in modelling DNA damage and cellular survival at the molecular level would be greatly enhanced when these contributions are factored in.
Figures





References
-
- Auger P. Sur les rayons b secondaires produits dans un gaz par des rayons X. C. R. Acad. Sci. D. 1925;180:65–68.
-
- Kassis A. I. The amazing world of Auger electrons. Int. J. Radiat. Biol. 2004;80:789–803. doi:10.1080/09553000400017663. - DOI - PubMed
-
- Kassis A. I., Adelstein S. J., Haydock C., Sastry K. S. R. Radiotoxicity of 75Se and 35S: theory and application to a cellular model. Radiat. Res. 1980;84:407–425. doi:10.2307/3575480. - DOI - PubMed
-
- Kassis A. I., Sastry K. S. R., Adelstein S. J. Kinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes. Radiat. Res. 1987;109:78–89. doi:10.2307/3576869. - DOI - PubMed
-
- Kassis A. I., Fayad F., Kinsey B. M., Sastry K. S. R., Taube R. A., Adelstein S. J. Radiotoxicity of 125I in mammalian cells. Radiat. Res. 1987;111:305–318. doi:10.2307/3576987. - DOI - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources