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Comparative Study
. 2011 Feb;49(2):710-1.
doi: 10.1128/JCM.01824-10. Epub 2010 Nov 24.

Rapid and sensitive loop-mediated isothermal amplification test for Clostridium difficile detection challenges cytotoxin B cell test and culture as gold standard

Torbjörn Norén  1 , Ingegärd Alriksson, Josefin Andersson, Thomas Akerlund, Magnus Unemo
Affiliations
Comparative Study

Rapid and sensitive loop-mediated isothermal amplification test for Clostridium difficile detection challenges cytotoxin B cell test and culture as gold standard

Torbjörn Norén et al. J Clin Microbiol. 2011 Feb.

Abstract

Compared to the composite gold standard cytotoxin B assay and toxigenic culture, the loop-mediated isothermal amplification (LAMP) test for Clostridium difficile had a sensitivity and specificity of 98%, positive predictive value of 92%, and negative predictive value of >99%. A one-hour turnaround time for the LAMP test provides rapid diagnosis and cost savings.

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References

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