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Clinical Trial
. 2011 Feb;123(2):98-104.
doi: 10.1111/j.1600-0404.2010.01361.x.

Physical inactivity, neurological disability, and cardiorespiratory fitness in multiple sclerosis

R W Motl  1 , M Goldman
Affiliations
Clinical Trial

Physical inactivity, neurological disability, and cardiorespiratory fitness in multiple sclerosis

R W Motl et al. Acta Neurol Scand. 2011 Feb.

Abstract

Objective: We examined the associations among physical activity, neurological disability, and cardiorespiratory fitness in two studies of individuals with multiple sclerosis (MS).

Method: Study 1 included 25 women with relapsing-remitting MS (RRMS) who undertook an incremental exercise test for measuring peak oxygen (VO₂(peak) ) consumption, wore an accelerometer during a 7-day period, and completed the Godin Leisure-Time Exercise Questionnaire (GLTEQ). Study 2 was a follow-up of Study 1 and included 24 women with RRMS who completed the self-reported Expanded Disability Status Scale (EDSS), undertook an incremental exercise test, wore an accelerometer during a 7-day period, and completed the GLTEQ.

Results: Study 1 indicated that VO₂(peak) was significantly correlated with accelerometer counts (pr = 0.69) and GLTEQ scores (pr = 0.63) even after controlling for age and MS duration. Study 2 indicated that VO₂(peak) was significantly correlated with accelerometer counts (pr = 0.50), GLTEQ scores (pr = 0.59), and EDSS scores (pr = -0.43) even after controlling for age and MS duration; there was a moderate partial correlation between accelerometer counts and EDSS scores (pr = -0.43). Multiple linear regression analysis indicated that both accelerometer counts (β = 0.32) and EDSS scores (β = -0.40) had statistically significant associations with VO₂(peak).

Conclusion: The findings indicate that physical inactivity and neurological disability might represent independent risk factors for reduced levels of cardiorespiratory fitness in this population.

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Figures

Figure 1
Figure 1
Scatter plots of the associations between objective and self-reporting measures of physical activity with cardiorespiratory fitness in a sample of 25 women with relapsing-remitting multiple sclerosis (Study 1).
Figure 2
Figure 2
Scatter plots of the associations between objective and self-reporting measures of physical activity, Expanded Disability Status Scale scores, and cardiorespiratory fitness in a sample of 24 women with relapsing-remitting multiple sclerosis (Study 2).
See this image and copyright information in PMC

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