Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;31(3):151-6.
doi: 10.1007/BF01744729.

Comparison of T suppressor factors from tumour-bearing mice and mice immunized with a monoclonal anti-idiotypic antibody

J M Greer  1 , W J Halliday
Affiliations

Comparison of T suppressor factors from tumour-bearing mice and mice immunized with a monoclonal anti-idiotypic antibody

J M Greer et al. Cancer Immunol Immunother. 1990.

Abstract

Certain dosage schedules of a monoclonal anti-idiotypic antibody (related to a murine bladder carcinoma) were found to induce suppressor factor production by syngeneic mice. This suppressor factor resembled the factor from tumour-bearing mice with respect to idiotype specificity, possession of molecular markers (reactive with anti-IJ and B16G antibodies) and production by Lyt2+IJ+ T cells in spleen cell cultures. The two factors differed with respect to Igh restriction in an in vitro assay (leucocyte adherence inhibition) and ability to suppress the induction of delayed-type hypersensitivity to tumour antigen.

PubMed Disclaimer

References

    1. Deal H, Steele JK, Stammers AT, Singhai R, Levy JG. Preadministration of a T-suppressor factor enhances tumor immunity in DBA/2 mice. Cancer Immunol Immunother. 1989;28:193. - PMC - PubMed
    1. Drebin JA, Waltenbaugh C, Schatten S, Benacerraf B, Greene MI. Inhibition of tumor growth by monoclonal anti I-J antibodies. J Immunol. 1983;130:506. - PubMed
    1. Greene MI, Fujimoto S, Sehon AH. Regulation of the immune response to tumor antigens. III. Characterization of thymic suppressor factor(s) produced by tumor-bearing hosts. J Immunol. 1977;119:757. - PubMed
    1. Greer JM, Halliday WJ. Auto-anti-idiotypic antibodies in mice hyperimmunized with a chemically induced bladder carcinoma. Immunol Cell Biol. 1988;66:167. - PubMed
    1. Halliday WJ, Miller S. Leukocyte adherence inhibition: a simple test for cell-mediated tumor immunity and serum blocking factors. Int J Cancer. 1972;9:477. - PubMed

MeSH terms

Substances

LinkOut - more resources