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. 1990;4(1):1-9.
doi: 10.1111/j.1472-8206.1990.tb01011.x.

Inhibition of human and rabbit platelet activation by Ketotifen

P Devillier  1 , B Arnoux, C Lalau Keraly, A Landes, J Marsac, J Benveniste
Affiliations

Inhibition of human and rabbit platelet activation by Ketotifen

P Devillier et al. Fundam Clin Pharmacol. 1990.

Abstract

The effects of Ketotifen and disodium cromoglycate were investigated on human and rabbit platelet activation. Ketotifen inhibited dose-dependently human and rabbit platelet aggregation. The paf-acether pathway was the most markedly influenced by Ketotifen in human and rabbit platelets (IC50 = 38.8 +/- 7.7 microM and 7.2 +/- 4.5 microM respectively) as compared to adenosine diphosphate (IC50 greater than 100 microM and 79 +/- 19 microM) and to arachidonic acid (IC50 greater than 100 microM and 98 +/- 28 microM). Similar concentrations of Ketotifen inhibited the ATP release from human platelets induced by paf-acether. Disodium cromoglycate up to 5 x 10(-4) M did not inhibit platelet aggregation induced by paf-acether, adenosine diphosphate and arachidonic acid.

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