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Clinical Trial
. 2010 Dec;151(5):430-4.
doi: 10.1111/j.1365-2141.2010.08387.x.

Southwest Oncology Group Study S0530: a phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia

Anjali S Advani  1 , Holly M Gundacker, Olga Sala-Torra, Jerald P Radich, Raymond Lai, Marilyn L Slovak, Jeffrey E Lancet, Steve E Coutre, Robert K Stuart, Martha P Mims, Patrick J Stiff, Frederick R Appelbaum
Affiliations
Clinical Trial

Southwest Oncology Group Study S0530: a phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia

Anjali S Advani et al. Br J Haematol. 2010 Dec.

Abstract

Clofarabine and cytarabine target different steps in DNA synthesis and replication, are synergistic in vivo, and have non-overlapping toxicities, making this combination a potentially promising treatment for acute lymphocytic leukaemia. Thirty-seven patients were treated. The median age was 41 years, 44% of patients were either in ≥2nd relapse or had refractory disease and 59% of patients had poor risk cytogenetics. Six out of 36 patients (17%) achieved a complete remission with or without complete count recovery; median overall survival was 3 months. Nucleoside transporter expression did not predict outcome. This regimen lacked sufficient activity to warrant further testing.

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Figures

Figure 1
Figure 1
Representative immunohistochemistry demonstrating a patient with low (0) hENT1 expression (A) and high (2+) hENT1 expression (magnification × 400).
Figure 1
Figure 1
Representative immunohistochemistry demonstrating a patient with low (0) hENT1 expression (A) and high (2+) hENT1 expression (magnification × 400).
See this image and copyright information in PMC

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