Prostate cancer: New insight into mechanisms of castration resistance

Comment

Sarah Payton. Nat Rev Urol. 2010 Nov.

. 2010 Nov;7(11):590.

doi: 10.1038/nrurol.2010.171.

No abstract available

Comment on

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant.
Sun S, Sprenger CC, Vessella RL, Haugk K, Soriano K, Mostaghel EA, Page ST, Coleman IM, Nguyen HM, Sun H, Nelson PS, Plymate SR. Sun S, et al. J Clin Invest. 2010 Aug;120(8):2715-30. doi: 10.1172/JCI41824. Epub 2010 Jul 19. J Clin Invest. 2010. PMID: 20644256 Free PMC article.
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor.
Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL. Watson PA, et al. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16759-65. doi: 10.1073/pnas.1012443107. Epub 2010 Sep 7. Proc Natl Acad Sci U S A. 2010. PMID: 20823238 Free PMC article.