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Review
. 2011 Jan 1;83(1):8-13.
doi: 10.1021/ac1018974. Epub 2010 Nov 29.

Before you analyze a human specimen, think quality, variability, and bias

Mark David Lim  1 , Anthony Dickherber, Carolyn C Compton
Affiliations
Review

Before you analyze a human specimen, think quality, variability, and bias

Mark David Lim et al. Anal Chem. .

Abstract

Personalized medicine requires capabilities to detect and measure health-associated biomarkers with increasingly specific and sensitive methods, putting analytical chemists at the front lines of translational research. Analytical scientists must be upstream in the experimental design process because the analysis of a biospecimen (tissue, blood, etc.) presents technical and experimental design complexities. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at pubs.acs.org/page/ancham/audio/index.html.).

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