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Review
. 2011 Aug;99(2):245-53.
doi: 10.1016/j.pbb.2010.11.009. Epub 2010 Nov 27.

The treatment of cognitive impairment in schizophrenia

Donald C Goff  1 , Michele Hill, Deanna Barch
Affiliations
Review

The treatment of cognitive impairment in schizophrenia

Donald C Goff et al. Pharmacol Biochem Behav. 2011 Aug.

Abstract

Cognitive deficits are major contributors to disability in schizophrenia. Many pharmacologic targets have been identified for cognitive enhancing agents, including receptors involved in dopaminergic, glutamatergic, GABAergic, serotonergic and cholinergic neurotransmission. In addition, new approaches to drug development have been directed towards neuroprotection and the facilitation of neuroplasticity. While several pharmacologic agents and cognitive remediation have shown promise in early trials, no treatment has yet demonstrated efficacy in large replication trials. The experience with different pharmacologic targets is reviewed and methodologic issues are discussed with recommendations for future research.

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