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. 2011 Feb;55(2):934-6.
doi: 10.1128/AAC.01247-10. Epub 2010 Nov 29.

Detection of NDM-1-producing Klebsiella pneumoniae in Kenya

Laurent Poirel  1 , Gunturu Revathi, Sandrine Bernabeu, Patrice Nordmann
Affiliations

Detection of NDM-1-producing Klebsiella pneumoniae in Kenya

Laurent Poirel et al. Antimicrob Agents Chemother. 2011 Feb.

Abstract

Seven carbapenem-resistant NDM-1-positive Klebsiella pneumoniae isolates were recovered from patients hospitalized between 2007 and 2009 in different wards at a referral and tertiary care center in Nairobi. Most of the isolates were obtained from urine. All isolates carried the bla(NDM-1) carbapenemase gene previously reported from India, Pakistan, and the United Kingdom. These isolates were clonally related and expressed many other resistance determinants, including β-lactamases CTX-M-15, OXA-1, OXA-9, CMY-6, and aminoglycoside resistance methylase RmtC. This work corresponds to the first report of NDM-1 producers in Africa.

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Figures

FIG. 1.
FIG. 1.
Pulsed-field gel electrophoresis patterns of the seven NDM-1-producing K. pneumoniae isolates from Nairobi and the single NDM-1-producing K. pneumoniae isolate from India. Lane 1, Kp1; lane 2, Kp2; lane 3, Kp3; lane 4, Kp4; lane 5, Kp5; lane 6, Kp6; lane 7, Kp7; lane 8, K. pneumoniae 05-506 (19); lane 9, K. pneumoniae 601 (11); lane 10, unrelated K. pneumoniae strain (included as a comparative strain).
See this image and copyright information in PMC

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