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Review
. 2010 Dec:(119):S22-6.
doi: 10.1038/ki.2010.418.

Mechanistic connection between inflammation and fibrosis

Soo Bong Lee  1 , Raghu Kalluri
Affiliations
Review

Mechanistic connection between inflammation and fibrosis

Soo Bong Lee et al. Kidney Int Suppl. 2010 Dec.

Abstract

Fibrosis of the kidney is caused by the prolonged injury and deregulation of normal wound healing and repair processes, and by an excess deposition of extracellular matrices. Despite intensive research, our current understanding of the precise mechanism of fibrosis is limited. There is a connection between fibrotic events involving inflammatory and non-inflammatory glomerulonephritis, inflammatory cell infiltration, and podocyte loss. The current review will discuss the inflammatory response after renal injury that leads to fibrosis in relation to non-inflammatory mechanisms.

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References

    1. Kisseleva T, Brenner D. Mechanisms of fibrogenesis. Exp Biol Med (Maywood) 2008;233:109–122. - PubMed
    1. Blank U, Essig M, Scandiuzzi L, et al. Mast cells and inflammatory kidney disease. Immunol Rev. 2007;217:79–95. - PubMed
    1. Ferguson M, O’Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004;359:839–850. - PMC - PubMed
    1. Martin P, Parkhurst S. Parallels between tissue repair and embryo morphogenesis. Development. 2004;131:3021–3034. - PubMed
    1. Kluth D, Erwig L, Rees A. Multiple facets of macrophages in renal injury. Kidney Int. 2004;66:542–557. - PubMed

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