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Review
. 2010 Oct 22:4:279-90.
doi: 10.2147/DDDT.S10180.

Liraglutide in the management of type 2 diabetes

Estela Wajcberg  1 , Amatur Amarah
Affiliations
Review

Liraglutide in the management of type 2 diabetes

Estela Wajcberg et al. Drug Des Devel Ther. .

Abstract

The pathophysiology of type 2 diabetes has been attributed to the classic triad of decreased insulin secretion, increased insulin resistance, and elevated hepatic glucose production. Research has shown additional mechanisms, including incretin deficiency or resistance in the gastrointestinal tract. Liraglutide is a modified form of human glucagon-like peptide-1. Liraglutide was obtained by substitution of lysine 34 for arginine near the NH2 terminus, and by addition of a C16 fatty acid at the ɛ-amino group of lysine (at position 26) using a γ-glutamic acid spacer. Liraglutide has demonstrated glucose-dependent insulin secretion, improvements in β-cell function, deceleration of gastric emptying, and promotion of early satiety leading to weight loss. Liraglutide has the potential to acquire an important role, not only in the treatment of type 2 diabetes, but also in preservation of β-cell function, weight loss, and prevention of chronic diabetic complications.

Keywords: diabetes mellitus; glucagon-like peptide; incretin; insulin resistance.

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Figures

Figure 1
Figure 1
Liraglutide structure.
See this image and copyright information in PMC

References

    1. Morrish NJ, Wang SL, Stevens LK. Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia. 2001;44(Suppl 2):S14–21. - PubMed
    1. DeFronzo RA. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus (Banting Lecture) Diabetes. 2009;58:773–795. - PMC - PubMed
    1. DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 2000;133:73–74. - PubMed
    1. Rossetti L, Shulman GI, Zawalich W, et al. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest. 1987;80:1037–1044. - PMC - PubMed
    1. McGarry JD. Banting Lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes. 2002;51:7–18. - PubMed

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