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Randomized Controlled Trial
. 2011 Feb;90(2):203-8.
doi: 10.1177/0022034510388516. Epub 2010 Nov 30.

The short-term effects of diammine silver fluoride on tooth sensitivity: a randomized controlled trial

J L Castillo  1 , S Rivera, T Aparicio, R Lazo, T-C Aw, L L Mancl, P Milgrom
Affiliations
Randomized Controlled Trial

The short-term effects of diammine silver fluoride on tooth sensitivity: a randomized controlled trial

J L Castillo et al. J Dent Res. 2011 Feb.

Abstract

Tooth sensitivity is a common clinical problem. This multi-center randomized clinical trial assessed the effectiveness and safety of topical diammine silver fluoride. From two sites (Lima and Cusco, Peru), 126 adults with at least one tooth sensitive to compressed air were randomly assigned to either the experimental treatment or sterile water, and pain was assessed by means of a 100-mm visual analogue scale at 24 hours and 7 days. The diammine silver fluoride reduced pain at 7 days at both sites. At the Lima site, the average change in pain scores between baseline and day 7 for the silver fluoride group was -35.8 (SD = 27.7) mm vs. 0.4 (SD = 16.2) mm for the control group (P < 0.001). In Cusco, the average change in pain scores for the silver fluoride group was -23.4 (SD = 21.0) mm and -5.5 (18.1) mm for the control group (P = 0.002). No tissue ulceration, white changes, or argyria was observed. A small number of participants in the silver fluoride group experienced a mild but transient increase in erythema in the gingiva near the tooth. No changes were observed in the Gingival Index. We concluded that diammine silver fluoride is a clinically effective and safe tooth desensitizer.

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Figures

Figure 1.
Figure 1.
Flow chart for clinical trial sites combined.
Figure 2.
Figure 2.
Root caries at baseline (left panel), 24 hrs after treatment (middle panel), and 7 days after treatment with diammine silver fluoride (right panel).
See this image and copyright information in PMC

References

    1. Arends J, Düschner H, Ruben JL. (1997). Penetration of varnishes into demineralized root dentin in vitro . Caries Res 31:201-205. - PubMed
    1. Chu CH, Lo EC, Lin HC. (2002). Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. J Dent Res 81:767-770. - PubMed
    1. Erdemir U, Yildiz E, Kilic I, Yucel T, Ozel S. (2010). The efficacy of three desensitizing agents used to treat dentin hypersensitivity. J Am Dent Assoc 141:285-296. - PubMed
    1. Hardin JW, Hilbe JM. (2002). Generalized estimating equations. New York, NY: Chapman & Hall/CRC Press.
    1. Jalali Y, Lindh L. (2010). A randomized prospective clinical evaluation of two desensitizing agents on cervical dentine sensitivity. A pilot study. Swed Dent J 34:79-86. - PubMed

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