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Randomized Controlled Trial
. 2010 Dec;197(6):448-55.
doi: 10.1192/bjp.bp.110.077289.

Treatment adherence therapy in people with psychotic disorders: randomised controlled trial

A B P Staring  1 , M Van der Gaag, G T Koopmans, J P Selten, J M Van Beveren, M W Hengeveld, A J M Loonen, C L Mulder
Affiliations
Randomized Controlled Trial

Treatment adherence therapy in people with psychotic disorders: randomised controlled trial

A B P Staring et al. Br J Psychiatry. 2010 Dec.

Abstract

Background: Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence.

Aims: To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly.

Method: Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159).

Results: Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve.

Conclusions: Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission.

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