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Case Reports
. 2010 Dec;340(6):499-504.
doi: 10.1097/MAJ.0b013e3181d94fa5.

H1N1-associated acute respiratory distress syndrome

Tathagat Narula  1 , Mathew Safley, Bennett P deBoisblanc
Affiliations
Case Reports

H1N1-associated acute respiratory distress syndrome

Tathagat Narula et al. Am J Med Sci. 2010 Dec.

Abstract

The worldwide 2009-2010 pandemic of novel H1N1 influenza reminds us that influenza can still be a lethal disease. Acute lung injury and acute respiratory distress syndrome (ARDS) have been the most devastating complications of this pathogen. We present a case of a previously healthy 40-year-old obese man who succumbed to H1N1-associated ARDS. In this focused review, we discuss the pathophysiologic peculiarities and management of acute lung injury/ARDS related to H1N1 infection.

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Figures

Figure 1
Figure 1
Postintubation anterior-posterior portable chest radiograph of a 40-year-old man with acute respiratory distress syndrome (ARDS) caused by proven novel 2009 H1N1 influenza. Sputum cultures were negative for bacterial pathogens.
Figure 2
Figure 2
Contrasted computed tomography (CT) angiogram of the thorax of the above patient was performed to look for evidence of pulmonary embolism. Lung windows demonstrate the parenchymal abnormalities. No pulmonary emboli were identified on this examination, although small segmental pulmonary emboli were found at autopsy.
Figure 3
Figure 3
Postmortem histopathology of the above patient. (A) Diffuse alveolar damage characterized by hyaline membrane formation and intraalveolar collections of denuded and reactive appearing pneumocytes. (B) Marked necrotizing bronchiolitis characterized by bronchial epithelial sloughing and necrosis with extensive subepithelial neutrophilic infiltrate. (C) Diffuse intraalveolar distention by recent hemorrhage.
None
See this image and copyright information in PMC

References

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