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Case Reports
. 2010 Mar;45(1):70-2.
doi: 10.5045/kjh.2010.45.1.70. Epub 2010 Mar 31.

A case of donor-derived granulocytic sarcoma after allogeneic hematopoietic stem cell transplantation

Seong Hyun Jeong  1 , Jae Ho Han, Seon Yong Jeong, Seok Yun Kang, Hyun Woo Lee, Jin-Hyuk Choi, Joon Seong Park
Affiliations
Case Reports

A case of donor-derived granulocytic sarcoma after allogeneic hematopoietic stem cell transplantation

Seong Hyun Jeong et al. Korean J Hematol. 2010 Mar.

Abstract

The occurrence of granulocytic sarcoma as a pattern of relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare. In this paper, we report a rare case of acute myeloid leukemia (AML) relapsed as a granulocytic sarcoma of the donor type. The patient was diagnosed as having AML and underwent an allo-HSCT from his matched sibling donor. Fifty-seven months after allo-HSCT, he developed granulocytic sarcomas of duodenum, jejunum, and left sterno-cleido-mastoid muscle. The bone marrow was normal with 100% donor chimerism. A Y chromosome PCR was performed on the patient's duodenum specimen as well as bone marrow aspirate in order to check the patient-origin cells. The duodenal specimen was found to contain 41.2% SRY-positive cells (from the donor). Repeat endoscopy on day 2 of chemotherapy showed that the granulocytic sarcoma had shrunk dramatically. The patient died of sepsis during the nadir state 35 days after starting salvage chemotherapy.

Keywords: AML; Allo-HSCT; Donor type; Granulocytic sarcoma.

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Figures

Fig. 1
Fig. 1
Endoscopic findings of the duodenal mucosal lesion.
Fig. 2
Fig. 2
Infiltrating cells were immunoreactive for CD34. Immunohistochemical stain. ×400.
Fig. 3
Fig. 3
Multiplex short tandem repeat polymerase chain reaction performed for the duodenal biopsy specimen shows that 41.2% of the cells were of donor origin.
See this image and copyright information in PMC

References

    1. Bèkássy AN, Hermans J, Gorin NC, Gratwohl A Acute and Chronic Leukemia Working Parties of the European Group for Blood and Marrow Transplantation. Granulocytic sarcoma after allogeneic bone marrow transplantation: a retrospective European multicenter survey. Bone Marrow Transplant. 1996;17:801–808. - PubMed
    1. Byrd JC, Edenfield WJ, Shields DJ, Dawson NA. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol. 1995;13:1800–1816. - PubMed
    1. Lee KH, Lee JH, Choi SJ, et al. Bone marrow vs extramedullary relapse of acute leukemia after allogeneic hematopoietic cell transplantation: risk factors and clinical course. Bone Marrow Transplant. 2003;32:835–842. - PubMed
    1. Breccia M, Mandelli F, Petti MC, et al. Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. Leuk Res. 2004;28:1165–1169. - PubMed
    1. Koc Y, Miller KB, Schenkein DP, Daoust P, Sprague K, Berkman E. Extramedullary tumors of myeloid blasts in adults as a pattern of relapse following allogeneic bone marrow transplantation. Cancer. 1999;85:608–615. - PubMed

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