Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun;137(6):959-64.
doi: 10.1007/s00432-010-0962-0. Epub 2010 Dec 1.

Association between age and synchronous liver metastasis in female colorectal cancer patients

Lin Wang  1 , Lei Wang, Wenbin Yu, Guangyong Zhang, Lifeng Zhang, Guihong Tian, Sanyuan Hu
Affiliations

Association between age and synchronous liver metastasis in female colorectal cancer patients

Lin Wang et al. J Cancer Res Clin Oncol. 2011 Jun.

Abstract

Purpose: The purpose of this study is to investigate the relationship between age and synchronous liver metastasis in female colorectal cancer patients.

Method: Clinical and pathological data from 655 consecutive female patients who were treated in Qilu Hospital from January 2000 to January 2010 were reviewed. First, the patients were divided into two groups: 60 years or younger and 61 years or older. A chi-square test was adopted to analyse the difference in clinicopathological characteristics between the two groups. Then, they were classified into two groups according to liver metastasis. Univariate analysis and logistic multivariate regression analysis were adopted to discriminate risk factors of liver metastasis.

Results: The chi-square test demonstrated that significant difference existed between the younger and the older groups in terms of liver metastasis (P < 0.001), lymph node metastasis (P < 0.001), tumour localization (P < 0.001), tumour invasion depth (P < 0.001), type of tumour (P < 0.001), tumour cell differentiation (P < 0.001) and venous invasion (P < 0.001). Univariate analysis demonstrated that seven factors are associated with liver metastasis. Logistic regression analysis indicated that age (P = 0.005), tumour size (P < 0.001), tumour invasion depth (P = 0.001), tumour cell differentiation (P = 0.029) and type of tumour (P < 0.001) are independent risk factors of liver metastasis.

Conclusions: The liver metastatic potential of colorectal cancer may be different between younger and older female patients. Age may independently influence liver metastasis in female colorectal cancer patients.

PubMed Disclaimer

Conflict of interest statement

All authors have no competing interest to declare.

Similar articles

See all similar articles

Cited by

References

    1. Adachi Y, Inomata M, Kakisako K, Sato K, Shiraishi N, Kitano S et al (1999) Histopathologic characteristics of colorectal cancer with liver metastasis. Dis Colon Rectum 42:1053–1056 - PubMed
    1. Barozzi C, Ravaioli M, D’Errico A, Grazi GL, Poggioli G, Cavrini G et al (2002) Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. Cancer 94:647–657 - PubMed
    1. Chen Z, Li M, Yuan Y, Wang Q, Yan L, Gu J et al (2010) Cancer/testis antigens and clinical risk factors for liver metastasis of colorectal cancer: a predictive panel. Dis Colon Rectum 53:31–38 - PubMed
    1. de Haas RJ, Wicherts DA, Salloum C, Andreani P, Sotirov D, Adam R et al (2010) Long-term outcomes after hepatic resection for colorectal metastases in young patients. Cancer 116:647–658 - PubMed
    1. De Jong KP, Stellema R, Karrenbeld A, Koudstaal J, Gouw AS, Sluiter WJ et al (1998) Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors. Hepatology 28:971–979 - PubMed