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Case Reports
. 2010 Nov;4(5):606-9.
doi: 10.1016/j.crohns.2010.05.004. Epub 2010 Jun 15.

Two cases of fatal Pneumocystis jirovecii pneumonia as a complication of tacrolimus therapy in ulcerative colitis--a need for prophylaxis

M Escher  1 , E F Stange, K R Herrlinger
Affiliations
Case Reports

Two cases of fatal Pneumocystis jirovecii pneumonia as a complication of tacrolimus therapy in ulcerative colitis--a need for prophylaxis

M Escher et al. J Crohns Colitis. 2010 Nov.

Abstract

Here we report 2 cases of fatal Pneumocystis jirovecii pneumonia in patients with severe ulcerative colitis receiving combination immunosuppression including tacrolimus. We discuss the necessity of a P. jirovecii prophylaxis especially in elderly patients according to the European evidence-based consensus on the prevention and management of opportunistic infections in inflammatory bowel disease.

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