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. 1978 Jul;53(2):209-16.
doi: 10.1530/jrf.0.0530209.

Target tissues for relaxin identified in vitro with 125I-labelled porcine relaxin

J P McMurtry, S C Kwok, G D Bryant-Greenwood

Target tissues for relaxin identified in vitro with 125I-labelled porcine relaxin

J P McMurtry et al. J Reprod Fertil. 1978 Jul.

Abstract

Various tissues from the mouse, rat and guinea-pig were used to examine the binding of a biologically active, esterified and 125I-labelled porcine relaxin. Binding to mouse symphysial homogenates was time- and temperature-dependent. Other peptide hormones did not complete with relaxin for binding. Mouse uterine tissue displayed similar binding characteristics. Fractionated mammary tissue from 15- and 20-day-pregnant rats exhibited significant relaxin binding activity, as did homogenates of the guinea-pig public symphysis and cervix. Under the conditions used, no relaxin receptors were noted in the liver, spleen or heart from any of the species investigated.

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