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. 2010 Nov 23;4(11):e895.
doi: 10.1371/journal.pntd.0000895.

Elimination of active trachoma after two topical mass treatments with azithromycin 1.5% eye drops

Abdou Amza  1 , Pablo Goldschmidt, Ellen Einterz, Pierre Huguet, Celine Olmiere, Philippe Bensaid, Lucienne Bella-Assumpta
Affiliations

Elimination of active trachoma after two topical mass treatments with azithromycin 1.5% eye drops

Abdou Amza et al. PLoS Negl Trop Dis. .

Abstract

Background: Following an epidemiological study carried out in 2006 showing a high prevalence of blinding trachoma in the Far North Region of Cameroon, a trachoma elimination programme using the SAFE strategy was initiated: three yearly trachoma mass treatments were to be performed.

Methodology/principal findings: The entire district population (120,000 persons) was treated with azithromycin 1.5% eye drops in February 2008 and January 2009. To assess the effect of treatment on the prevalence of active trachoma, three epidemiological studies were conducted on a representative sample of children aged between 1 and 10 years. The first study was performed just prior to the first treatment, the second just prior to the 2nd treatment and the third one, one year later. The prevalence of active forms of trachoma (TF + TI) dropped from 31.5% (95%CI 26.4-37.5) before treatment to 6.3% (95%CI 4.1-9.6) one year after first treatment; a reduction of nearly 80%. One year after the second treatment, the prevalence decreased to 3.1% (95%CI 2.0-4.9), a total reduction of 90%. Furthermore, there were no more TI cases (only TF). There was no report of serious or systemic side effects. Tolerance was excellent.

Conclusions/significance: Active trachoma mass treatment with azithromycin 1.5% eye drops is feasible, well tolerated, and effective.

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Conflict of interest statement

Pierre Huguet and Céline Olmiere are employees of Laboratoires Théa. No competing interest to declare for other authors.

Figures

Figure 1
Figure 1. Flow chart of the study.
Figure 2
Figure 2. Prevalence of active trachoma in children aged between 1 and 10 years.
See this image and copyright information in PMC

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References

    1. Solomon AW, Zondervan M, Kuper H, Buchan J, Mabey D, et al. Trachoma control. A guide for programme managers. 2006:1–53.
    1. Hu VH, Harding-Esch EM, Burton MJ, Bailey RL, Kadimpeul J, et al. Epidemiology and control of trachoma: systematic review. Trop Med Int Health. 2010;15:673–691. - PMC - PubMed
    1. Cromwell EA, Courtright P, King JD, Rotondo LA, Ngondi J, et al. The excess burden of trachomatous trichiasis in women: a systematic review and meta-analysis. Trans R Soc Trop Med Hyg. 2009;103:985–992. - PubMed
    1. World Health Organization (WHO) Report of the 2nd Global Scientific Meeting on Trachoma. Geneva, Switzerland, 25-27 August, 2003. WHO/PBD/GET 03. 2003;1:1–28.
    1. Bensaid S, Huguet P, Goldschmidt P, Einterz E. Le trachome au Cameroun: résultats d'une enquête épidémiologique dans le district de Kolofata dans la province de l'Extrême-Nord. Rev Int Trach Pathol Ocul Trop Subtrop Santé Publique. 2007;84:79–103.

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